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  6. Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
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    Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.

    Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.

    The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
    “This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.

    First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.

    Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.

    “We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”

    Harming infant health
    The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.

    Within a day or two of birth, the authors collected the babies’ blood via a heel stick.

    The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.

    Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.

  8. Абразивные и алмазные инструменты Klingspor
    Абразивные и алмазные инструменты торговой марки Klingspor – достойный выбор профессионалов во всех промышленных отраслях. Для поиска фирм, где можно осуществить покупку специализированных инструментов, необходимо перейти в раздел «Где купить» и выбрать свой регион. Будет представлен список адресов и телефонов компаний, реализующих товар торговой марки. Выберите из списка фирму, осуществляющую продажу абразивных материалов, алмазных дисков в Москве, Санкт-Петербурге, Новосибирске, Екатеринбурге, Нижнем-Новгороде, Казани и других городах России, чтобы сделать заказ.

    Каталог абразивной и алмазной продукции Klingspor, представленный на сайте, носит информационный характер. На страницах веб-ресурса размещены полные данные о абразивных, алмазных и твердосплавных изделиях данной немецкой марки, чтобы потребитель имел представление об его технических характеристиках и конкурентных преимуществах. Тогда, прежде чем купить абразивные материалы, потребитель сможет внимательно изучить свойства продукции и решить, какой товар подойдет, а какой нет.

    АБРАЗИВНЫЕ ИНСТРУМЕНТЫ ИЗ ШЛИФОВАЛЬНОЙ ШКУРКИ
    Каталог периодически пополняется новыми товарными позициями, которые весьма быстро становятся популярными. Например, отмечается активный спрос на абразивные инструменты из шлифовальной шкурки. Они представляют собой полотно ткани (бумаги) с нанесенным на него слоем абразива. С их помощью очень легко осуществить обработку самых разных поверхностей. В частности, абразивный инструмент из шлифовальной шкурки может применяться для шлифования металлических, деревянных изделий и лакированных поверхностей. В том числе с его помощью легко выполнить зачистку ржавчины или старой краски. Как показывает практика, он отлично справляется с данной задачей. В каталоге представлено несколько образцов абразивного инструмента из шлифшкурки. Повышенной популярностью пользуются абразивные круги на бакелитовой связке, алмазные диски и разнообразные абразивные насадки на шлифмашинки. Изучите имеющееся к товару описание, найдите торгового представителя фирмы Klingspor в любом из российских регионов и оформите заказ.

    Абразивные изделия марки чрезвычайно популярны во всем Мире и все больше и больше находят почитателей в России, Белоруссии, Украине, Казахстане. География продажи в России расширяется из года в год. Уже сейчас инструменты Klingspor вы можете купить оптом и в розницу в Москве, Санкт-Петербурге, Новосибирске, Екатеринбурге, Нижнем-Новгороде, Омске, Казани и др.

    Если купить абразивы и абразивный инструмент не удается, так как не можете самостоятельно найти или выбрать подходящий товар, то, возможно, следует обратиться за консультацией. Задайте свои вопросы консультантам магазинов, и они обязательно на них ответят. Информационная база данных постоянно обновляется, что расширяет возможности при поиске нужной абразивной и алмазной продукции. Желаем вам безопасного и успешного использования абразивных изделий.

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